Signatures of Introgression across the Allele Frequency Spectrum
نویسندگان
چکیده
منابع مشابه
Non-equilibrium theory of the allele frequency spectrum.
A forward diffusion equation describing the evolution of the allele frequency spectrum is presented. The influx of mutations is accounted for by imposing a suitable boundary condition. For a Wright-Fisher diffusion with or without selection and varying population size, the boundary condition is lim(x downward arrow0)xf(x,t)=thetarho(t), where f(.,t) is the frequency spectrum of derived alleles ...
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We develop the theory for computing the joint frequency spectra of alleles in two closely related species. We allow for arbitrary population growth in both species after they had a common ancestor. We focus on the case in which a single chromosome is sequenced from one of the species. We use classical diffusion theory to show that, if the ancestral species was at equilibrium under mutation and ...
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One of the main necessities for population geneticists is the availability of statistical tools that enable to accept or reject the neutral Wright-Fisher model with high power. A number of statistical tests have been developed to detect specific deviations from the null frequency spectrum in different directions (i.e., Tajima’s D, Fu and Li’s F and D test, Fay and Wu’s H). Recently, a general f...
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15 صفحه اولAsymptotics of the allele frequency spectrum associated with the Bolthausen-Sznitman coalescent
We imagine a coalescent process as modelling the genealogy of a sample from a population which is subject to neutral mutation. We work under the assumptions of the infinitely many alleles model so that, in particular, every mutation gives rise to a completely new type in the population. Mutations occur as a Poisson process of rate ρ along the branches of the coalescent tree. The allelic partiti...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2020
ISSN: 1537-1719
DOI: 10.1093/molbev/msaa239